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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disease
PNH often manifests with complement-mediated hemolysis, anemia, and fatigue1
Both intravascular hemolysis (IVH) and extravascular hemolysis (EVH) occur in patients with PNH and can result in persistent symptoms that may impact patients' daily lives2-5
Complement inhibitors given by infusion require patients to adapt their lives around scheduling infusion treatment6
Learn about the signs, symptoms, and complications of PNH
References: 1. Dingli D et al. Ann Hematol. 2022;101(2):251-263. 2. Cançado RD et al. Hematol Transfus Cell Ther. 2021;43(3):341-348. 3. Brodsky RA. Blood. 2009;113(26):6522-6527. doi:10.1182/blood-2009-03-195966 4. Hill A et al. Haematologica. 2010;95(4):567-573. 5. Risitano AM et al. Blood. 2009;113(17):4094-4100. 6. Levy AR et al. Blood. 2019;134(suppl 1):4803.